Erhaltungstherapie mit Methadontabletten - Eine Übersicht
Erhaltungstherapie mit Methadontabletten - Eine Übersicht
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If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
Published animal data have reported increased neonatal mortality rein the offspring of male rodents that were treated with methadone prior to mating. In these studies, the female rodents were not treated with methadone, indicating paternally-mediated developmental toxicity. Specifically, methadone administered to the male rat prior to mating with methadone-naive females resulted rein decreased weight gain rein progeny after weaning. The male progeny demonstrated reduced thymus weights, whereas the female progeny demonstrated increased adrenal weights. Further, behavioral testing of these male and female progeny revealed significant differences rein behavioral tests compared to control animals, suggesting that paternal methadone exposure can produce physiological and behavioral changes rein progeny in this model. Other animal studies have reported that perinatal exposure to opioids including methadone alters neuronal development and behavior in the offspring. Perinatal methadone exposure hinein rats has been linked to alterations hinein learning ability, Aggregat activity, thermal regulation, nociceptive responses and sensitivity to drugs.
For women who are breastfeeding: Methadone may pass into breast milk and may cause side effects hinein a child World health organization is breastfed.
Zidovudine – Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result rein toxic effects.
Some heartbeat problems have happened rein people using smaller doses of methadone hydrochloride tablets for treatment of narcotic drug addiction.
Prevent theft and misuse. Keep your methadone hydrochloride tablets hinein a safe place to protect them from theft. Never give methadone hydrochloride tablets to anyone else even if they have the same symptoms you have.
Abnormal fetal nonstress tests (NSTs) have been reported to occur more frequently when the test is performed 1 to 2 hours after a maintenance dose of methadone rein late pregnancy compared to controls.
Intravenously administered naloxone or nalmefene may be used to reverse signs of intoxication. Because of the Methadontabletten ohne Rezept online relatively short half-life of naloxone as compared with methadone, repeated injections may be required until the status of the patient remains satisfactory. Naloxone may also Beryllium administered by continuous intravenous infusion.
For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of methadone in your body and cause more side effects. Your doctor should watch you closely if you take this drug.
Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to Grenzwert abuse of opioid drugs.
The rate at which methadone is decreased should Beryllium determined separately for each patient. The dose of methadone can Beryllium decreased on a daily Lager or at 2-day intervals, but the amount of intake should remain sufficient to keep withdrawal symptoms at a tolerable level. In hospitalized patients, a daily reduction of 20% of the total daily dose may Beryllium tolerated. Hinein ambulatory patients, a somewhat slower schedule may be needed.
Some data also indicate that methadone acts as an antagonist at the Stickstoff-methyl-Durchmesser eines kreises-aspartate (NMDA) receptor. The contribution of NMDA receptor antagonism to methadone's efficacy is unknown. Other NMDA receptor antagonists have been shown to produce neurotoxic effects in animals.
Dosage adjustment using higher doses or administering the daily dose hinein divided doses may be necessary rein pregnant women treated with methadone (see CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION).
Take your next dose the following day as scheduled. Don’t take extra doses. Taking more than the prescribed dose may cause you to overdose because this drug builds up hinein your body over time.